Q: In the movie W., where Josh Brolin plays George "Dubya" Bush, the actor playing CIA director George Tenet shouts "Mulaka!" at one point. What does it mean?
A: Mulaca is Greek slang that's the equivalent of the British "wanker." You can translate the word as asshole, dick, bastard or son of a bitch, depending on the context.
The more standard variation of mulaka is malakas μαλάκας. It is an interjection that foreigners in Greece pick up easily.
Former CIA director George Tenet is of Greek heritage. It is very likely George Stephanopoulos also knows what the word malaka means, and has probably used it a couple of times as well.